HMGCR and COVID-19: The present MR study provided a suggestive evidence regarding the positive association of the HMGCR expression and HMGCR-mediated LDL cholesterol level with the risk of COVID-19 hospitalization, both of which together indicated a potential protective effect of HMGCR inhibition against COVID-19 hospitalization (OR instrument 1 = 0.72, 95% CI = 0.55–0.95; OR instrument 2=0.76, 95% CI = 0.57–1.00).