Genetic mutations responsible for human brain diseases such as Rett-like phenotype (Lopes et al., 2016; Vuillaume et al., 2018; Yoo et al., 2017), infantile epileptic spasms (Hamdan et al., 2017), and epileptic encephalopathy (Hamdan et al., 2017; Yoo et al., 2017) were identified in GABBR2 (which encodes GB2), with most of them resulting in missense mutations in TM3 and TM6. The gene discussed is GABBR2; the disease is Epileptic encephalopathy.