As discussed above, IL-6 elevation also has been demonstrated in severe neurological involvement as in other organ systems affected by hypercytokinemic inflammation.4,7,14 This excess IL-6 release can play a major role in the pathogenesis or simply be an epiphenomenon of other cytokine releases.34 As a result, IL-6 stands out as an important cornerstone indicating serious organ involvement in CS. Here, IL6 is linked to Cowden syndrome 1.