Additionaly, tumor-released exosomal circ-PDE8A absorbed miR-338 to regulate metastasis associated in colon cancer 1 and promoted the invasive growth of pancreatic ductal adenocarcinoma cells via the metastasis associated in colon cancer /MET/extracellular regulated protein kinases or protein kinase B pathways [12]. Here, PDE8A is linked to colonic neoplasm.