However, the coexistence of HTN and hyperglycemia exerted either synergistic effects to promote renal dysfunction and injury as reflected by increases in 24-h urinary albumin excretion, reduced GFR, or additive effects to exacerbate histological injury in glomeruli and tubules in the right kidneys of WT mice with DM and exposed to increased BP. This evidence concerns the gene ALB and hypertensive disorder.