As shown in Fig. 4B, urinary albumin excretion was markedly increased in the right kidneys of WT-DM + AC mice (0.5 ± 0.1 μg/min, exposed to hyperglycemia and high BP) compared with the left kidneys of the same animals (0.2 ± 0.1 μg/min, exposed only to hyperglycemia) as well as the right kidneys from WT-AC mice (0.3 ± 0.1 μg/min, exposed only to high BP) and the right kidneys in WT-DM mice (0.3 ± 0.1 μg/min, exposed only to hyperglycemia). This evidence concerns the gene ALB and Hyperglycemia.