Further multivariable analysis after backward selection based on AIC showed that sarcopenia (HR = 1.55; 95% CI: 1.02–2.36; p = 0.040), multiple tumors (HR = 1.85; 95% CI: 1.25–2.73; p = 0.002), VI (HR = 1.78; 95% CI: 1.19–2.64; p = 0.005), an R1 margin (HR = 2.27; 95% CI: 1.07–4.82; p = 0.033), LN involvement (HR = 3.25; 95% CI: 1.87–5.65; p < 0.001), and elevated CEA (HR = 1.47; 95% CI: 0.94–2.29; p = 0.095) were independent prognostic factors (Table 2). The gene discussed is CEACAM5; the disease is sarcopenia.