In addition, some studies have provided strong experimental evidence supporting a role for immunoproteasome in modulating NF‐κB signalling under conditions of ischaemic stroke or inflammation response,10,21 Immunoproteasome‐mediated proteolysis has emerged as an important molecular mechanism in the regulation of wide‐ranging functions, both immune (such as antigen presentation) and non‐immune (including antioxidative stress),9,22 Thus, we revealed a mechanism by which the immunoproteasome regulate the expression of NLRP3 inflammasomes by facilitating the NF‐κB signalling pathway activation. Here, NLRP3 is linked to ischemic stroke.