The management of high-risk GI cancer screening through endoscopic surveillance [often coupled with risk-reducing surgery in FAP and hereditary diffuse gastric cancer (HDGC)], starting from as young as age 10–11 y in FAP and 18 y in HDGC, in individuals with an APC or CDH1 variant has been universally accepted since clinical recognition of these conditions. Here, APC is linked to Familial gastric cancer.