Chang et al. observed that the G allele of IL1R1 rs3917225 conferred a decreased risk of age-related hearing impairment (ARHI) and that both the GG genotype of IL1R1 rs3917225 in all studied hereditary models and the TT genotype of IL1R2 rs2071008 in the studied recessive model conferred decreased risks of ARHI [14]. Here, IL1R1 is linked to presbycusis.