BDNF and age-related macular degeneration: In this line, it has been reported that serum and aqueous humour BDNF levels are lower in patients with NE-AMD [59], that BDNF intravitreal injections protects PR against light damage [60, 61], and that increased BDNF expression delays PR death and protects retinal function in a mouse model of primary PR degeneration [62].