In one study using a murine model of IDH1 mutated AML, vitamin C exposure induced a pattern of differentially methylated regions that overlapped with enhancers implicated in myeloid differentiation, specifically regions related to the hematopoietic-specific TFs: CEBPβ, HIF1α, RUNX1, and PU.1. Here, RUNX1 is linked to acute myeloid leukemia.