Interestingly, while knockdown of HOXD-AS1 in PCa cells resulted in a significantly reduced expression of FOXM1, treating the cells with CRPC-Exos obviously upregulated FOXM1 expression, and reversed the downregulation of FOXM1 caused by HOXD-AS1 depletion (Fig. 5M). This evidence concerns the gene FOXM1 and posterior cortical atrophy.