Variants in other interaction partners of NCOA3 including insulin growth factor 1 (IGF1 rs5742643), HNF1 homeobox A (HNF1A rs1800574 and rs56348580), and IQ motif containing K (IQCK rs7185636) were associated with systolic blood pressure [66, 67], type 2 diabetes [68–72], or Alzheimer’s disease [47], respectively. This evidence concerns the gene IGF1 and early-onset autosomal dominant Alzheimer disease.