The inhibition of RORγt also attenuated the effects of anti-miRNA-221-5p on the increased levels of IL-6, IL-17, IL-21 and IL-22 levels, and inhibited levels of IL-10, IL-35 and TGF-β in in vitro model of asthma following anti-miRNA-221-5p, in comparison with anti-miRNA-221-5p group (Fig. 7D–J). Here, IL21 is linked to asthma.