The expression of miRNA-221-5p was increased in model of asthma, compared with negative group (Fig. 2A) The vitro model of asthma treated with miRNA-221-5p mimic resulted in the reduction of IL-6, IL-17, IL-21 and IL-22 levels, and induction of IL-10, IL-35 and TGF-β levels. The gene discussed is IL22; the disease is asthma.