The inhibition of FOXP3 attenuated the effects of miRNA-221-5p on the inhibition of IL-6, IL-17, IL-21 and IL-22 levels, and promotion of IL-10, IL-35 and TGF-β levels in in vitro model of asthma following anti-miRNA-221-5p, in comparison with anti-miRNA-221-5p group (Fig. 8D–J). The gene discussed is IL21; the disease is asthma.