The inhibition of SOCS1 attenuated the effects of anti-miRNA-221-5p on the increased levels of IL-6, IL-17, IL-21 and IL-22, and suppressed levels of IL-10, IL-35 and TGF-β in in vitro model of asthma following anti-miRNA-221-5p, compared with anti-miRNA-221-5p group (Fig. 6E–K). Here, IL21 is linked to asthma.