IDH1 and glioblastoma: Histological glioblastomas predicted to be IDH-wildtype glioblastomas had the same median overall survival (1.1 years), and their survival trajectory was significantly worse than those of histological grade 4 tumors that were predicted to be IDH-mutant astrocytomas (HR = 0.78, p = 0.004, log-rank) (Fig. 6E).