IDH1 and astrocytoma (excluding glioblastoma): Predicted REMBRANDT IDH-mutant astrocytomas are also disproportionately older and higher grade than TCGA IDH-mutant astrocytomas, although the same is not true of predicted REMBRANDT and TCGA 1p/19q-codeleted oligodendrogliomas (Additional file 2: Fig. 14).