When compared to controls, the upregulated mRNAs were primarily enriched in pathways associated with rheumatoid arthritis, ferroptosis, taurine and hypotaurine metabolism, IL-17 signaling pathway, mineral absorption, epithelial cell signaling in H. pylori infection, collecting duct acid secretion, synaptic vesicle cycle, necroptosis, and bladder cancer (Fig. 4C). This evidence concerns the gene IL17A and rheumatoid arthritis.