We discovered some genes enriched linked to tumor proliferation signaling pathway, including 13 genes that were associated with Wnt signaling pathway, 10 genes with Ras/MAPK signaling pathway, 4 genes with PI3K-Akt signaling pathway,2 genes with p53 signaling pathway, 2 genes with VEGF signaling pathway and 4 genes with Jak-STAT signaling pathway (Fig. 5E and Additional file 6). The gene discussed is TP53; the disease is neoplasm.