It is reported that a slight submucosal linear enhancement is associated with nonmuscle invasiveness condition in BCa [37], and the DCE-based radiomics features have been successfully used for the prediction of Ki67 expression in liver cancer [33], breast cancer [30, 36] and thyroid cancer [31], which may facilitate the application of DCE-based features for Ki67 expression prediction in BCa. The gene discussed is MKI67; the disease is thyroid cancer.