ANGPTL4 and metabolic dysfunction-associated steatotic liver disease: Moreover, the association of lpl overexpression and accumulation of liver triglycerides with NAFLD has been shown in the literature, while the overexpression of hepatic Angptl4 seems to inhibit LPL in peripheral tissues [41, 42] and play an important role in the protection of fat accumulation [43] and FA-related inflammation [44].