In addition, recent relevant studies have also shown that some candidate tumor gene biomarkers were recognized as targets of glioma, and 4 genes (NDUFS5, NDUFA1, NDUFA13, and NDUFB8) of the candidate tumor gene biomarkers belonged to the NADH ubiquinone oxidoreductase subunit gene family, indicating that this gene family may have a strong correlation with glioma. Here, NDUFS5 is linked to central nervous system cancer.