In addition, our other data supports that knocking out MMP12 in ApcMin/+ mice may reduce insulin levels or increase insulin sensitivity, which could contribute to reversing insulin resistance (Fig. S6A-H), while it was not related to the basic function of islets based on results of H&E staining and IHC staining (Fig. S4E-H). The gene discussed is MMP12; the disease is Insulin resistance.