P2RX7 and migraine disorder: Taken together the above evidence and given that NMDA receptor facilitates CSD initiation and propagation [1, 26], we propose that P2X7 receptor/SFKs signaling promotes cortical susceptibility to CSD and CSD-associated glutamate release, which subsequently may sustain NMDA receptor activity and create a positive feedback loop, contributing to CSD-associated migraine pathogenesis.