The molecular mechanisms underlying CSD-induced migraine is not fully understood, but activation of membrane receptors and channels, some of which are N-methyl-D-aspartic acid (NMDA) receptors [11], gamma-Aminobutyric acid receptors [12], purinergic P2X7 receptor [13], transient receptor potential ankyrin 1 [14] and Pannexin-1 (Panx1) [7], have been well known to contribute to migraine pathogenesis. This evidence concerns the gene PANX1 and migraine disorder.