In nitroglycerin (NTG)-induced mouse migraine model, inhibition of P2X7 receptor activity attenuates mechanical and thermal hyperalgesia, inflammatory response and central sensitization via promoting autophagic process in trigeminal nucleus caudalis (TNC) [17, 18]; whilst the recurrent NTG in turn increases P2X7 receptor protein expression in TNC [18]. This evidence concerns the gene P2RX7 and migraine disorder.