On the other hand, the proliferation of breast cancer cells, retinal progenitor cells, human astrocytes, preadipocytes could be inhibited by IL-4, and it remained controversy on its effects on proliferation of B cells (Silva et al. 2008; Estes et al. 1993; Hua et al. 2004; Blais et al. 1996; Llorente et al. 1990). This evidence concerns the gene IL4 and breast cancer.