IL-4 was reported to prevent the osteoclastogenesis in numerous studies (Mangashetti et al. 2005), while Dou et al. explored that IL-4 induced M2 macrophages tended to be more likely differentiate into osteoclasts comparing with M1 macrophages in osteoporosis model (Dou et al. 2018). The gene discussed is IL4; the disease is osteoporosis.