MTOR and Parkinson disease: In a mouse model of PD, levels of phosphorylated mTOR (Ser2448) (p-mTOR) in the substantia nigra were increased [20], and pretreatment with the p-mTOR inhibitor rapamycin partially prevented the cell death induced by 6-OHDA [21], exerting a neuroprotective effect in cellular and animal models of PD [22].