In Pancreatic tissue, including PAAD (Pancreatic adenocarcinoma) Tumor, PAAD normal and pancreas, the activation of mTOR was associated with gene mutations, including KRAS, TP53, CKDN2A, and SMAD4, resulting in tumor development (Figure 4A, 4B). The gene discussed is TP53; the disease is pancreatic adenocarcinoma.