The hypermethylation of MGMT was concomitant with a loss of MGMT expression in CLD and HCC (CLD log2FC = −0.99, q = 0.007, HCC log2FC = −1.80, q = 9.04e−8; Fig. 3B, bottom). The gene discussed is MGMT; the disease is congenital secretory chloride diarrhea 1.