MAT1A and congenital secretory chloride diarrhea 1: In support of this hypothesis, we found progressive loss of expression of MAT1A (CLD q = 0.02, Log2FC = −0.80, HCC q = 1.43e−11, Log2FC = −2.14; Table S1B,C), which catalyses synthesis of the universal methyl donor S‐adenosylmethionine (SAM) as previously reported in cirrhotic livers [47].