TSC2 and congenital secretory chloride diarrhea 1: The genes affected by the epigenetic priming occurring in CLD included hypermethylated regions associated with the cytochrome P450 family gene CYP2C19 and tuberous sclerosis complex 2 (TSC2), both downregulated in the CLD and HCC samples and reported to be lost in HCC with implications for prognosis [55, 56].