However, here, using two cohorts, we expand upon these by showing the extent and impact of DNA methylation changes in CLD is more far‐reaching than has previously been reported, affecting genes for which aberrant methylation has not, to our knowledge, been reported in CLD, for example CYP2C19, TSC2 and TAGLN2. The gene discussed is TSC2; the disease is congenital secretory chloride diarrhea 1.