In NSCLC, the enhanced infiltration of CD8 T cells and M1 macrophages (both p < 0.05), reduced infiltration of M2 macrophages (p = 0.026), and immune response‐relevant circuits (e.g., antigen processing and presentation, graft‐versus‐host disease, and allograft rejection) were also observed in PTPRT‐mutated patients (Figure S8A,B). Here, CD8A is linked to non-small cell lung carcinoma.