In this WES NSCLC cohort, the markedly increased TMB and NB were found in PTPRT mutant patients (median TMB: 4.91 vs. 3.84, median NB: 9.27 vs. 7.73, both p < 0.001; Figure 6A,B). The gene discussed is PTPRT; the disease is non-small cell lung carcinoma.