Moreover, several upregulated genes including CEACAM1, CEACAM6, CEACAM8 in TCGA, and HOXA3, HOXA5, HOXB5, and HOXB6 in TARGET were also found in,37 although the high‐risk subgroup was only compared to the low‐risk subtype in their study, Finally, previous study discovered promoter hypermethylation of genes CDH1 and WT1 in AML,38 we further demonstrate that CDH1 and WT1 are upregulated in adult AML. This evidence concerns the gene HOXA3 and acute myeloid leukemia.