Moreover, several upregulated genes including CEACAM1, CEACAM6, CEACAM8 in TCGA, and HOXA3, HOXA5, HOXB5, and HOXB6 in TARGET were also found in,37 although the high‐risk subgroup was only compared to the low‐risk subtype in their study, Finally, previous study discovered promoter hypermethylation of genes CDH1 and WT1 in AML,38 we further demonstrate that CDH1 and WT1 are upregulated in adult AML. Here, HOXB6 is linked to acute myeloid leukemia.