Although RGS10 and FAM26F are not upregulated in TARGET cohort, we discover that one gene (RGS3) of the regulator of G‐protein signaling (RGS) family is upregulated, and several other members of Family With Sequence Similarity (FAM) including FAM30A, FAM124A, FAM47E, and FAM81A are also upregulated in childhood tumor. Here, PITX2 is linked to neoplasm.