We identify three novel RBPs and their targets specifically for high‐risk adult AML, More interestingly, the RBP MLLT3 interacts with three small nucleolar RNAs (snoRNAs) including SNORD116‐4, SNORD116‐20, and SNORD116‐28, which belong to the noncoding SNORD116 gene cluster. Here, MLLT3 is linked to acute myeloid leukemia.