NRIP1 (Nuclear receptor‐interacting protein 1) is the host gene of the circular RNA circNRIP1, and itself is a circRNA that modulates both transcriptional activation and repression, and plays an important role in the regulation of different cancer pathways, whereas PTK2 (Protein Tyrosine Kinase 2) is the host gene of the circRNA circPTK2, and itself is also a circRNA according to.46, 47. The gene discussed is PTK2; the disease is cancer.