Furthermore, we discover that two RBPs, MLLT3 and RBPMS, and their circRNA targets PTK2 and NRIP are significantly associated with the OS of adult AML, whereas two different RBPs, MSI2 and DNMT3B, and 13 (out of 17) of lncRNA targets are prognostically significant in childhood AML, providing potential therapeutic targets for AML. Here, DNMT3B is linked to acute myeloid leukemia.