The CCCTC‐binding factor (CTCF) binding motif was enriched at the TSS of genes with a dmCpG associated with grip strength (FDR = 0.0142) and in the gene bodies of genes associated with sarcopenia (FDR = 2.73 × 10−3), ALMi (FDR = 0.0185), gait speed (FDR = 4.88 × 10−3), and grip strength (FDR = 1.23 × 10−5). Here, CTCF is linked to sarcopenia.