Three promising analogs representing a complex anti‐AD mechanism (free radical scavenger, AChE inhibitor, binding the mGluR5 and NMDA receptors and inhibiting the progression of Aβ fibrillation) include methyl 4‐hydroxy‐8‐methoxy‐5‐nitroquinoline‐2‐carboxylate, methyl 8‐amino‐4‐hydroxy‐6‐methoxyquinoline‐2‐carboxylate, and methyl 5‐amino‐4‐hydroxy‐8‐methoxyquinoline‐2‐carboxylate. The gene discussed is GRM5; the disease is Alzheimer disease.