Genetically mimicked effects of statins via HMGCR inhibition were positively associated with the risk of asthma in East Asians overall (odds ratio (OR) 2.05 per standard deviation (SD) decrease in LDL-C, 95% confidence interval (CI) 1.20 to 3.52, p value 0.009), although the p value did not reach the Bonferroni corrected significance level. This evidence concerns the gene HMGCR and asthma.