In addition, 9 pathways were specifically active in the hypertension group, including signaling pathways that regulate vascular development in the embryo and were reactivated following vascular injury (EGF, BMP, RANKL, WNT, and ANGPT)41–44 and pathways that have not been fully studied in the cardiovascular system, such as PERIOSTIN, NPR1, and CHEMERIN. This evidence concerns the gene RARRES2 and hypertensive disorder.