PKM and cancer: The Kaplan–Meier curves indicated that patients with high PD-L1 and PKM2 expressions in cancer cells conferred significantly worse prognosis than those with low PD-L1 and PKM2 expressions (PD-L1hi + PKM2hi vs. PD-L1lo + PKM2lo; P = 0.039; HR, 3.019; 95% CI, 1.348–1.775) (Fig. 1g).