Using the Differential Enrichment analysis of Proteomics data (DEP) R software package [40], we reinterrogated the recently published dynamic LSD1 interactome upon treatment of NB4 acute promyelocytic leukemia (APL) cells with the LSD1 inhibitor MC2580 (Fig. 1A) [13] and we found that, in addition to the already-described GFI1, interaction with GSE1 protein was also significantly downregulated after drug treatment (Fig. 1B and C). The gene discussed is KDM1A; the disease is acute promyelocytic leukemia.