In summary, by describing for the first time the molecular and cellular implications of GSE1 modulation in AML, this study paves the way for a thorough assessment of the role of this chromatin factor in hematological malignancies and the possibility of targeting it with LSD1 inhibitors, to trigger myeloid differentiation for treatment of this type of tumor. The gene discussed is KDM1A; the disease is acute myeloid leukemia.