TNFRSF8 and classic Hodgkin lymphoma: To actually confirm that the identified clonotypes were of neoplastic cell origin, we enriched the HRS cells in FF and FFPE material of two cHL cases (case 8 and 16) using laser microdissection (LMD) of CD30+ HRS cells in FF tissue sections, and flow cytometric isolation of CD30+MUM1+ HRS cells after mild enzymatic digestion of the paired FFPE tissue specimen, as described by Juskevicius et al.29.