Clusters 0 and 1, which were observed to increase in relative proportion upon UM-002 treatment in vivo (Fig. 6D), are characterized by increased relative expression of mesenchymal GBM cell state markers such as SERPINE1, MT2A, TIMP1, NDRG1, BNIP3, and MT1E, as well as expression of the OPC-like markers LIMA1 and PSAT1 (Fig. 7A)31. Here, SERPINE1 is linked to glioblastoma.