For example, hyperactivation of RIPK1 in Tbk1/Tak1 double heterozygous mice leads to comorbidity of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which is attenuated by one allele of kinase-dead RIPK140. The gene discussed is TBK1; the disease is amyotrophic lateral sclerosis.