APOE and dementia: Also, compared with other biomarkers including APOE genotype, ADAS-cog score, Abeta and pTau measures, pattern probabilities show either comparable or significantly superior performance in prediction of both CN to MCI and MCI to Dementia progression (Fig. 5d, p = 0.15 for pattern vs ADAS-Cog in MCI-Dementia prediction and p < 0.001 for comparison between pattern and all other biomarkers).