Consistent with the cell line results, lung tumors in the conditional KRAS-G12D mouse30 expressed higher levels of EZH2 protein than the non-tumor lung tissue; there was cytoplasmic EZH2 (Fig. 7a–c), DLC1 protein levels were lower in the tumors than the adjacent non-tumor tissue (Supplementary Fig. 8C), and EZH2 and DLC1 formed a complex in lung tumor extracts (Fig. 7d). This evidence concerns the gene KRAS and neoplasm.