RB1 and cancer: A strong association between olaparib sensitivity and RB1 status extended to a poly-cancer cell line panel, with median area-under-the-curve (AUC) values significantly lower in RB1-defective compared to RB1-normal lines (Supplementary Fig. 1d–f), indicative that RB1 status in cancers is associated with, and may predict, hypersensitivity to PARPi.