CCT8 and colorectal carcinoma: In order to explore the CCT8-related signal pathway, we analyzed the CRC-related gene expression data in the public database TCGA (n = 478) (https://portal.gdc.cancer.gov), and found that p53 signal pathway (GO:1901796) was enriched in CCT8 high expression group (gene set enrichment analysis, GSEA) (p value = 0.012; q value = 0.025) (Fig. 4A).