CCT8 and colorectal carcinoma: It is worth noting that gene enrichment analysis (gene set enrichment analysis, GSEA) using CRC-related gene expression data (478 cases) in the public database TCGA (https://portal.gdc.cancer.gov/) also found that cell cycle (hsa04110) and EMT transformation (GO:0001837) were closely related to the expression of CCT8 (p value = 8.60e-8, q value = 9.33e-7; p value = 0.003, q value = 0.005) (Fig. 5B).