Indeed, impaired microtubule dynamics disrupts autophagic clearance (Aplin et al, 1992; Fass et al, 2006; Boecker & Holzbaur, 2019; Farfel-Becker et al, 2019), and defects in autophagy contribute to AD pathogenesis (Nixon et al, 2005; Yang et al, 2008; Sanchez-Varo et al, 2012) by promoting the accumulation of Aβ and tau (Babu et al, 2008; Zheng et al, 2012; Xu et al, 2019). Here, MAPT is linked to Alzheimer disease.