Previously, Liu et al (2013) and Thathiah et al (2013) have shown that both β-arrestin1 (Liu et al, 2013) and β-arrestin2 (Thathiah et al, 2013) are increased in AD brains and promotes Aβ production by interacting with the γ-secretase subunit Aph-1 (Liu et al, 2013; Thathiah et al, 2013), thereby linking β-arrestin1 and β-arrestin2 to Aβ pathogenesis. This evidence concerns the gene APH1A and Alzheimer disease.