Considering the low frequency of functional neoepitopes, multiplexing strategies are of particular importance for related vaccine approaches.12 15 To assess how effectively multivalent immunization with CPQ would present neoepitopes and induce Ag-specific CD8+ T cells in vivo, the Nes2LR neoepitope was combined with 19 or 59 other irrelevant neoepitopes from the CT26 murine cancer cell line (peptide CT1-CT59, described in our recently published work22). Here, CD8A is linked to cancer.