CPQ liposomes were recently shown to potently induce Ag-specific CD8+ T-cell responses when admixed with nanogram doses of short peptide immunogens in prophylactic and therapeutic tumor models.22 23 In the present work, we make use of next-generation sequencing technology with highly multiplexed CPQ particles to identify a short neoepitope capable of cancer ablation in the RENCA mouse model of RCC. The gene discussed is CD8A; the disease is cancer.