When including the discovery OC family, there was an increased carrier frequency of c.1813C>T in BRCA1 and BRCA2 pathogenic variant negative OC families versus sporadic OC cases (P = 0.01, Fisher’s exact) and cancer-free females (3/23, 13%; OR = 5.8; 95%CI = 1.7-19; P = 0.005). This evidence concerns the gene BRCA1 and cancer.