Our findings are reminiscent of the identification of specific variants in familial FC cancer populations of Quebec, such as RAD51D c.620C>T; p.S207L in familial and sporadic OC cases [33], PALB2 c.2323C>T; p.Q775X in BC cases and HBC families [32, 110], and MSH6 c.10C>T; p.Q4X in colorectal cancer (Lynch Syndrome) families [111]. Here, MSH6 is linked to breast cancer.