FANCI c.1813C>T; p.L605F has been reported in ClinVar as benign or likely benign (n = 6 submissions) in the context of FANCA associated FA (n = 1), FANCI-associated FA (n = 2), or unspecified conditions (n = 3) with only in silico (no in cellulo or in vitro) evidence provided to classify this variant and no information on zygosity in carriers nor cancer context. The gene discussed is FANCI; the disease is cancer.