Pathogenic BRCA1 and BRCA2 variants have been reported in 65–85% of cancer syndromes featuring high-grade serous ovarian carcinoma (HGSC) [6], the most common histopathological subtype of epithelial OC [7], and in 10–20% of HGSC cases regardless of age at diagnosis [8]. This evidence concerns the gene BRCA1 and cancer.