With these promising results in hand, we assessed FANCI c.1813C>T carrier frequency in available PBL DNA from index OC or BC cases of FC ancestry to determine if this variant plays a role in conferring risk in phenotypically defined cancer families [17–20, 22, 23, 30, 32, 33, 40, 41, 79, 85–90]. Here, FANCI is linked to cancer.