GP2 and familial pancreatic carcinoma: The lead variant is rs78193826, a missense variant (C>T: p.V432M) located within the coding region of GP2. Individuals carrying the risk allele T had an approximately 1.5-fold increased risk of pancreatic cancer compared with individuals with the alternative allele C. Of interest are wide variations in the risk allele frequency of rs78193826 across populations, as it ranges from 3 to 8% in Asian populations versus nearly 0% in populations of European and African ancestry.