Network pharmacology analysis showed that ShuangHuangLian oral liquid (the active formulations included quercetin, beta-sitosterol, neobaicalein) shared 28 targets with COVID-19, such as caspase-3, tumor protein p53 (TP53), MAPK8, IL-6, CCL-2, and the main pathways related to hepatitis b, TNF signaling pathway, pulmonary tuberculosis, whooping cough, salmonella infection, swine flu, as well as herpes simplex virus infection pathway [45]. The gene discussed is TP53; the disease is pertussis.