In a rat model of lipopolysaccharides (LPS)-induced pneumonia, the thrombin and TLR signaling pathway were demonstrated to be essential pathways for MaXingShiGan Decoction mediated anti-inflammatory effects, while glycyrrhizic acid (one major compound in MXSG) inhibited TLR agonists induced IL-6 production in macrophage [73]. This evidence concerns the gene IL6 and pneumonia.