The network analysis of MaXingShiGan Decoction in severe COVID-19 predicted its main active components (quercetin, kaempferol, wogonin, naringenin, and isorhamnetin) with key targets including CCL-2, IL-1β, IL-4, IL-6, IL-10, MAPK1, MAPK3, MAPK8, TNF, caspase-3, Akt1, TP53, VEGFA, epidermal growth factor (EGF), and EGF receptor (EGFR) [74, 75]. Here, CASP3 is linked to COVID-19.