OPTN and neurodegenerative disease: In addition to AD, OPTN was also identified to be expressed in the spinal cords of amyotrophic lateral sclerosis (ALS), Lewy bodies and Lewy neurites of Parkinson’s disease, ballooned neurons of Creutzfeldt–Jakob disease, glial cytoplasmic inclusions of multiple system atrophy, and Pick bodies of Pick’s disease, suggesting that OPTN may represent a more general marker for neurodegenerative diseases [78].