CASP1 and Alzheimer disease: In a subsequent study, APP/PS1/NLRP3−/− mice exhibited reduced caspase-1 cleavage and Aβ deposition and enhanced phagocytosis of Aβ compared to APP/PS1 mice, providing evidence that NLRP3 plays an in vivo and exacerbating role in the pathogenesis of AD [45].