The results demonstrated that the mRNA and protein expression of OPTN was downregulated in the cerebral cortex and hippocampus of 9-month-old APP/PS1 Tg mice compared to that of WT mice (Fig. 1E–G), which is consistent with the transcriptomic sequencing data from AD patients (Fig. 1A–D). This evidence concerns the gene OPTN and Alzheimer disease.