AKT1 and colorectal cancer: MED4-AS1 is a novel lncRNA that is upregulated in NSCLC and is positively associated with poor differentiation and metastasis [48], The lncRNA small nucleolar RNA host gene 7 (SNHG7) was considered as an oncogenic lncRNA in NSCLC, hepatocellular carcinoma, breast cancer, and colorectal cancer [49, 50], which was found to modulate malignant character in LUAD through SNHG7/miRNA-181/cbx7 pathway, and mediates cisplatin-resistance in NSCLC through activating PI3K/AKT pathway [51].