It turned out circSERPINA3 knockdown led to reduced level of Bcl-2 and elevated levels of Bax and Cleaved-PARP1 in PCa cells, while circSERPINA3 overexpression resulted in opposite results in PCa cells and WPMY-1 cells (Additional file 1: Figure S1E–I). The gene discussed is PARP1; the disease is posterior cortical atrophy.