After that, Caspase3 and Caspase9 activity was detected when sh-SERPINA3 or pcDNA3.1-SERPINA3 was transfected into PCa cells (Fig. 4E–H), and results demonstrated that both Caspase3 and Caspase9 activities rose after SERPINA3 knockdown, whereas their activities declined after SERPINA3 up-regulation. The gene discussed is SERPINA3; the disease is posterior cortical atrophy.