We also tested lactate content (Fig. 4O, P), PK activity (Fig. 4Q, R) and ECAR/OCR value (Fig. 4S, T) in PCa cells and found that SERPINA3 reduction led to the decrease in lactate content, PK activity and ECAR/OCR value of PCa cells. This evidence concerns the gene SERPINA3 and posterior cortical atrophy.