A previous study systematically reported the genetic and clinical data for 20 patients with pathogenic TANC2 mutations for the first time in 2019, as a follow-up of a recent meta-analysis of whole-exome sequencing (WES) data from 10,927 families with neurodevelopmental disorders (NDDs), which include autism spectrum disorder (ASD) and epilepsy [4]. Here, TANC2 is linked to neurodevelopmental disorder.